ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression.

Both the median tumor volume and the volume of the largest tumor showed a trend towards reduced tumor size without statistical significance (Fig. 2I ), whereas the overall tumor burden showed a non-significant trend towards increased tumor burden after twelve weeks but no difference after 20 weeks of treatment (Fig. 2J ).

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Interestingly, after 20 weeks of treatment, the tumor number seemed to be slightly elevated in Acsl4 Δhepa compared to Acsl4 f/f mice, although this difference did not reach statistical significance (Fig. 2G ).

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