Leptin mediates the regulation of muscle mass and strength by adipose tissue.

Type 2b were the only fibres with lower CSA in FF compared with WT muscle, approaching significance ( P = 0.06) at 6 weeks of age with a significant reduction by 16 weeks (Fig. 1 F ).

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However, increases in protein synthesis in leptin treated FF mice were relatively moderate and increases in phospho‐mTOR and phospho‐S6 ribosomal protein did not reach statistical significance suggesting another pathway such as autophagy could also be involved.

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