The relationship between primary colorectal cancer histology and the histopathological growth patterns of corresponding liver metastases.

Tumour interface markers Peritumoural budding (grade II/III vs I: 20% vs 10%) and an infiltrative CRC growth pattern (53% vs 42%) were also more common for patients with corresponding non-desmoplastic versus desmoplastic metastases, but again these differences did not reach statistical significance ( p = 0.18 and p = 0.28 respectively, Table 2 ).

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But again, the lack of statistical power was evident, as multiple markers – Including established prognosticators such as lymph-node positivity – demonstrated clinically relevant estimates but failed to reach statistical significance based on the estimate uncertainty (supplementary file 2 ).

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