Early life sleep disruption potentiates lasting sex-specific changes in behavior in genetically vulnerable Shank3 heterozygous autism model mice.

Additionally, in adolescent Shank3 ΔC/ΔC mice compared to WT, we observed reductions in sleep bout length in the light phase in the female group (female p = 0.0053; male closely approached significance at p = 0.0532) and both sexes in the dark phase (male p = 0.0199, female p = 0.0215) (Fig. 1 C, D).

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5 D), albeit, these individuals still showed a trend toward preference for the novel stranger 2 (PASD HET p = 0.085; PASD WT p = 0.011), suggesting that social novelty behavior in genetically vulnerable males is sensitive to sleep disruption at later ages of development, consistent with recent reporting [ 10 ].

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