Influence of Glutathione-S-Transferase A1*B Allele on the Metabolism of the Aromatase Inhibitor, Exemestane, in Human Liver Cytosols and in Patients Treated With Exemestane.

A near-significant ( P trend = 0.060) trend was also observed for urinary EXE-cys levels from the same patients.

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A significant trend toward decreasing levels of EXE-cys ( P trend = 0.0067) and 17 β -DHE-cys ( P trend = 0.028) was observed in plasma in subjects with increasing numbers of the GSTA1*B allele.

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Similarly, there was a nonsignificant trend ( P trend = 0.060) toward decreasing levels of urinary EXE-cys in subjects with increasing numbers of the GSTA1*B allele ( Fig. 3A ), with urinary EXE-cys levels 15% lower for subjects with the GSTA1 *B*B genotype (0.56 EXE-cys/TEM) as compared with subjects with the GSTA1 *A*A genotype (0.66 EXE-cys/TEM).

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