Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome.

Nat Cardiovasc Res · 2022 · PMC9431959 · PMID 36051854

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did not reach statistical significanceno p-value reported

The result suggest that there was a trend towards an increased hERG-WGA co-localization in dextromethorphan-treated TS cardiomyocytes compared with non-treated ones while the change did not reach statistical significance ( Ext.

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showed a trendno p-value reported

When we examined the changes in Kcnq1 transcripts in mouse hearts, dextromethorphan treatment did not significantly upregulate the transcription of Kcnq1 in TS hearts although TS hearts showed a trend towards a reduction in Kcnq1 gene expression compared with control hearts ( Ext.

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