a significant trendp < 0.0001
Over the study period, a significant trend was seen over the years in the following parameters: lower age (84 ± 5.6, 83.7 ± 6.2, 82.1 ± 6.3 and 80.3 ± 6.6 in groups 1–4, respectively p < 0.0001), lower female ratio (60%, 53%, 52% and 44% in groups 1–4, respectively p < 0.0001), lower body surface area (1.79 ± 0.21, 1.8 ± 0.19, 1.81 ± 0.21 a