Evidence of genetic overlap and causal relationships between blood-based biochemical traits and human cortical anatomy.

Although the weighted median and MR Egger methods did not reach statistical significance, both causal estimates were directionally consistent (Fig. 5a, b , Table S 10 ).

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No causal estimates were statistically significant, apart from the IVW m estimator after covarying for mean cortical TH, which was nominally significant ( β IVWm = 0.025, SE IVWm = 0.012, P IVWm = 0.038; Fig. 5a, b , Tables S 9 & S 10 ).

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