MAP3K4 promotes fetal and placental growth by controlling the receptor tyrosine kinases IGF1R/IR and Akt signaling pathway.

Map3k4 KI/KI livers isolated at E13.5 were also reduced in size when compared with Map3k4 WT/WT livers, but these differences did not reach statistical significance ( p = 0.0535) ( Fig. 2 , C and D ; Table S3 ).

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Although examination of the median IGF1R/IR phosphorylation showed a clear trend with decreasing phosphorylation in Map3k4 KI/KI placentas, these changes in placental IGF1R/IR phosphorylation did not reach statistical significance.

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