The combination of DNA methylome and transcriptome revealed the intergenerational inheritance on the influence of advanced maternal age.

Among the four DEGs observed in oocyte, MED12L , one mother‐offspring intergenerationally correlated DEGs downregulated in the AMA group, showed a trend toward downregulation in both mothers and offspring in qRT‐PCR validation, but statistical significance was reached only in the mother group (Figure S8B,C ).

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The mean value was approximately 75% in each group, and it was slightly lower in the AMA group than in the Young group for both maternal and paternal samples, but the difference did not reach statistical significance (Figure 1C,D ).

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