SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition.

Because hIAPP:SORLA KO islets showed a trend towards reduced insulin positive islet area ( Figure S1B , ND: WT 59.2 ± 1.2% vs KO 56.3 ± 1.1%, p = 0.10), while glucagon positive islet area was comparable between SORLA genotypes ( Figure S1C , ND: WT 11.3 ± 0.5% vs KO 11.3 ± 0.9%, p = 0.97), we suspect apoptotic cells are likely to be beta cells.

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At 30–32 weeks of age, hIAPP:SORLA KO mice trended to show signs of impaired glucose tolerance, but this finding did not reach statistical significance ( Figure S2C ).

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