From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems.

Transl Psychiatry · 2022 · PMC9489881 · PMID 36127322

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.1500

boldest claim

The sentences

showed a trendp = 0.054so close (0.05 < p ≤ 0.1)

Quantitative autoradiography findings Two-way ANOVA of striatum (Caudate putamen) in all three models showed a trend for interaction between strain and genetic modification ( p = 0.054).

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did not reach statistical significancep = 0.15not close (p > 0.1)

GABA + levels were lower in the ASD group as compared to non-ASD, but this did not reach statistical significance ( t (12) = 1.5, p = 0.15, d = 0.23).

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