Furthermore, a nonsignificant trend towards beneficial effects of genetic liability to long sleep duration (≥9 h/d) (MVP: OR, 0.82 [CI, 0.59–1.12]; GoLEAD‐SUMMIT: OR, 0.75 [CI, 0.56–1.00]) was observed.
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Causal Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Peripheral Artery Disease: A Mendelian Randomization Approach.
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However, even though a similar trend was observed, the IVW failed to reach statistical significance in the GoLEAD‐SUMMIT cohort (OR, 1.13 [CI, 0.99–1.30]) and most sensitivity analyses except for the contamination mixture analysis (OR, 1.18 [CI, 1.08–1.29]).
The suspicion of pleotropic inference was strengthened by the results of the MR‐PRESSO analysis, in which the estimates changed significantly after exclusion of outliers (distortion test P value: 0.05), and the corrected estimate did not reach statistical significance when corrected for multiple testing (OR, 1.26 [CI, 1.05–1.51], P value: 0.02).