Early Dynamics of Quantitative <i>SEPT9</i> and <i>SHOX2</i> Methylation in Circulating Cell-Free Plasma DNA during Prostate Biopsy for Prostate Cancer Diagnosis.

Cancers (Basel) · 2022 · PMC9496792 · PMID 36139516

Europe PMC DOI

hedged sentences

0.2800

closest p · 5.6× alpha

0.2800

boldest claim

The sentences

did not reach statistical significancep = 0.28not close (p > 0.1)

Baseline mSHOX2 - and mSEPT9 -ccfDNA levels were moderately increased in men with PCa compared to healthy men; however, this finding did not reach statistical significance ( p = 0.28 and 0.18).

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a strong trendno p-value reported

The static single measurement of the methylation status of both SEPT9 and SHOX2 showed a strong trend for hypermethylation in PCa patients but did not reliably distinguish between healthy individuals and men suffering from PCa.

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