<i>NBN</i>, <i>RAD51</i> and <i>XRCC3</i> Polymorphisms as Potential Predictive Biomarkers of Adjuvant Radiotherapy Toxicity in Early HER2-Positive Breast Cancer.

As eight SNPs from three genes were investigated in our study, Bonferroni correction was used to account for multiple comparisons: p -values below 0.006 were considered statistically significant, while p -values between 0.006 and 0.050 were considered nominally significant.

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Similarly, in a meta-analysis, a significant association of XRCC3 rs861539 with increased acute RT toxicity was observed, while the association with late adverse events did not reach statistical significance.

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