Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis.

Young’s modulus showed a strong trend of reduction in treated scars, with 5/6 treated scars recording a lower YM than their matched vehicle treated scar (Fig. 8g , p = 0.15), suggesting PXS-6302 treated scars are more pliable than their placebo-treated controls.

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4b ) while HLNL showed a trend reduction at the highest tested concentration (Fig. 4c ).

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