Comprehensive Transcriptomic and Proteomic Analyses Identify a Candidate Gene Set in Cross-Resistance for Endocrine Therapy in Breast Cancer.

AKT1S1 , SCG5 , CEACAM1 , and ALOX12B reached borderline significance between the CR and PD groups ( p = 0.022 to 0.09).

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Finally, based on PFS, we filtered and arranged 29 targets with inclusion criteria: (1) response AUC ≥ 0.6 and PFS ≤ 0.05 in both TR and ET cohorts ( AKT1S1 , NSL1 , ESRRA , TMEM81 , CKB , SGEF ); (2) statistical significance in PFS/OS of two cohorts ( KRT19 ); (3) borderline significance between CR and PD ( SCG5 , CEACAM1 , ALOX12B ) and seven targets with inclusion criteria; (4) statistical significance in PFS of TR or ET cohort.

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However, the score from RPPA did not reach statistical significance in the endocrine therapy cohort of PFS/OS.

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