Patterns and distribution of de novo mutations in multiplex Middle Eastern families.

First, the cohort size within each disease category may have been too underpowered to detect significant differences in pairwise comparisons; however, even when we amalgamated several disorders together to compare against controls, the resulting differences by count and by predicted impact did not reach statistical significance.

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In our study cohort, we observed a nominally significant correlation; however, this correlation appeared to be confounded by both the father’s age at conception (consanguineous couples in our cohort conceived earlier) and the availability of more siblings in consanguineous families (larger kindreds).

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