Concerning substantia nigra contrast-to-noise ratio in other disorders, there is a similar trend for increase in substance use disorder, no clear trend in major depressive disorder, no studies in bipolar disorder, and a clear trend for reduction in Parkinson’s disease.
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Magnetic resonance imaging of the dopamine system in schizophrenia - A scoping review.
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The sentences
In patients with schizophrenia, studies of VTA/substantia nigra resting-state BOLD FC demonstrated an overall trend to reduced functional connectivity between VTA/substantia nigra and forebrain structures in patients ( 145 – 147 ).
In resting-state BOLD fMRI, there was a weak trend for reduced resting-state functional connectivity of dopaminergic nuclei with forebrain regions, whose interpretation is difficult since the direction of BOLD changes cannot easily be interpreted.
Resting-state BOLD fMRI studies in schizophrenia showed a trend for reduced resting-state functional connectivity of dopaminergic nuclei with widespread forebrain areas ( 145 – 147 ) ( Figure 5 ).