Suppression of estrogen receptor beta classical genomic activity enhances systemic and adipose-specific response to chronic beta-3 adrenergic receptor (β3AR) stimulation.

Front Physiol · 2022 · PMC9534559 · PMID 36213237

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0960

boldest claim

The sentences

a strong trendp = 0.056so close (0.05 < p ≤ 0.1)

CL significantly increased O2 consumption in all stimulated states (T, p < 0.020, all ), and there was a strong trend detected in the basal state (T, p = 0.056, trend ).

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did not reach statistical significancep = 0.096so close (0.05 < p ≤ 0.1)

When the data were analyzed as a whole (males and females combined), CL’s ability to reduce HFD-induced body weight gain did not reach statistical significance (T, p = 0.096, trend ).

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highly significantno p-value reported

Our previous work in rodents ( Queathem et al., 2021 ) and humans ( Porter et al., 2020 ) has already established a highly significant, consistent, and strong correlation between these proteins in WAT.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.