Is cyclooxygenase-1 involved in neuroinflammation?

J Neurosci Res · 2021 · PMC9542093 · PMID 34346520

Europe PMC DOI

hedged sentences

0.0470

closest p · 0.9× alpha

0.0540

boldest claim

The sentences

marginally significantp = 0.047actually significant

Nonmedicated patients showed a marginally significant increase in COX‐2 expression ( p = 0.047) and a significantly (−62%) reduced cPGES expression in frontal cortex ( p ≤ 0.001), compared to controls.

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approached significancep = 0.054so close (0.05 < p ≤ 0.1)

Medicated patients did not show any differences in the expression level of COX‐2 and cPGES compared to controls, except for a 27% decrease in cPGES in the frontal cortex of patients with BP that approached significance ( p = 0.054).

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did not reach statistical significanceno p-value reported

Subjects with dementia showed an almost twofold higher expression of the COX‐1 gene than nondemented subjects, but the difference did not reach statistical significance because of a high interindividual variability in the patient groups.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.