Serological biomarkers of type I, III and IV collagen turnover are associated with the presence and future progression of stricturing and penetrating Crohn's disease.

Aliment Pharmacol Ther · 2022 · PMC9544881 · PMID 35661188

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0100

boldest claim

The sentences

nominally significantp = 0.010actually significant

Taken together, the balance between type III collagen formation and degradation (C3M/PRO‐C3 ratio) was higher in patients with non‐stricturing, non‐penetrating CD (Montreal B1) compared with HCs (albeit only nominally significant, p = 0.010; Table S2 ).

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showed a trendno p-value reported

No significant differences in serum C1M (after adjustment for multiple comparisons) and C6Ma3 levels were observed between disease behaviour subclasses (i.e., without considering HC), although patients with stricturing disease showed a trend towards lower levels than the remaining patients.

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