Genetic and functional analyses implicate microRNA 499A in bipolar disorder development.

Transl Psychiatry · 2022 · PMC9547016 · PMID 36207305

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showed a trendno p-value reported

2F ) showed a trend towards a reduction in the levels of mature miR-499a as well as pre-miR-499a in HEK293T cells transfected with the mutant miR-499a construct, which is consistent with impaired Drosha-mediated pri-miR-499a processing secondary to the mutation.

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nominally significantno p-value reported

Of the various repeat alleles, only the 11 repeat allele showed a nominally significant overrepresentation in BD patients compared to controls ( p nom = 0.009).

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