Combined brain-derived neurotrophic factor and neurotrophin-3 treatment is preferred over either one separately in the preservation of the auditory nerve in deafened guinea pigs.

Front Mol Neurosci · 2022 · PMC9549372 · PMID 36226314

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hedged sentences

0.0580

closest p · 1.2× alpha

0.0780

boldest claim

The sentences

close-to-significantp = 0.058so close (0.05 < p ≤ 0.1)

An LMM analysis revealed a treatment effect [ F (3,94.7) = 7.3, p < 0.001] and interaction effect between treatment and location [ F (3,122.5) = 5.4, p = 0.0015], with a strongly significant treatment effect for the BDNF-treated animals [ t (91.0) = 4.6, p < 0.001] and with a close-to-significant treatment effect for both NT-3 and Cocktail groups [ t NT–3(93.7) = 1.9, p = 0.058; t Cocktail(96.1) = 1.8, p = 0.076].

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almost significantp = 0.070so close (0.05 < p ≤ 0.1)

NT-3 treatment also led to a smaller Δthreshold than PBS, which was almost significant ( p = 0.070).

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approaching significancep = 0.078so close (0.05 < p ≤ 0.1)

No interaction effect, but approaching significance, between treatment and location was observed [ F (3,98.1) = 2.3, p = 0.078].

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