Development and validation of an online prognostic nomogram for osteosarcoma after surgery: a retrospective study based on the SEER database and external validation with single-center data.

Univariate analysis suggested that age, sex, pathological subtype (ICD-O-3 Hist/behave), primary site, grade, AJCC-T, AJCC-N, AJCC-M, tumor size, tumor extension, surgery type, radiation, and chemotherapy were significantly associated with CSS (all P≤0.05), whereas race, marital status, and laterality failed to reach statistical significance (P>0.05) ( Table 2 ).

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Unexpectedly, univariate Cox regression showed that chemotherapy patients appear to be related to poor survival, although it did not reach statistical significance in multivariate analysis ( Table 2 ).

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