Exposure to silica and systemic sclerosis: A retrospective cohort study based on the Canadian Scleroderma Research Group.

Furthermore, silica exposure increased the risk of dcSSc and ATA positivity by almost 50% and increased the risk of severe ILD by twofold, with a confidence interval near statistical significance despite adjusting for multiple confounders.

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Furthermore, silica exposure was associated with worse SSc outcomes in these patients such as younger age at SSc diagnosis and a strong trend toward higher risk of dcSSc, ATA antibodies, more severe GI disease, ILD, and mortality.

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