The risk of major osteoporotic fractures with GLP-1 receptor agonists when compared to DPP-4 inhibitors: A Danish nationwide cohort study.

Front Endocrinol (Lausanne) · 2022 · PMC9589410 · PMID 36299454

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0510

boldest claim

The sentences

near-significantp = 0.051so close (0.05 < p ≤ 0.1)

This test revealed a near-significant protective effect of the GLP-1 RAs compared to DPP-4is with a slope of -0.0042 (p = 0.051).

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highly significantno p-value reported

When estimating HRs for MOF in the full unmatched cohort, the unadjusted analysis yielded a highly significant difference between the groups.

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a clear trendno p-value reported

When examining different thresholds for MPR, a clear trend was apparent with larger difference in fracture risk for increasing MPR thresholds between the GLP-1 RA group and the DPP-4i group.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.