Therapeutic Effect of IL-21 Blockage by Gene Therapy in Experimental Autoimmune Encephalomyelitis.

Neurotherapeutics · 2022 · PMC9606180 · PMID 35902536

Europe PMC DOI

hedged sentences

0.1180

closest p · 2.4× alpha

0.1380

boldest claim

The sentences

did not reach statistical significancep = 0.118not close (p > 0.1)

2 c, sIL21R-treated mice showed a tendency to lose less weight than the control group, however, the differences did not reach statistical significance (AUC of weight change for Null: −56.37 ± 197.00, n = 18; sIL21R: 48.23 ± 199.60, n = 19; p = 0.118).

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showed a trendp = 0.138not close (p > 0.1)

5 a, b), the experimental group administered on day +1 also showed a trend towards clinical worsening (mean clinical score AUC (Null: 21.33 ± 15.70, n = 6; sIL21R: 35.70 ± 13.03, n = 7; p = 0.138), weight change AUC (Null: 142.10 ± 79.28, n = 6; sIL21R: 25.89 ± 139.00, n = 7; p = 0.099)) (Fig. 5 c, d).

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