The 48^th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Poster Session (P001 - P578).

Among cases with mixed chimerism in the whole blood, as determined by PCR -based method, there was a highly significant positive correlation between the two methods (Pearson r = 0.651, p > 0.0001).

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Overall, 8 patients in group A (25%) and 6 patients in group B (8.8%) developed MDR-gram negative BSI, unveiling a marginally significant trend towards the reduction of MDR gram-negative BSI after withholding FQ prophylaxis ( p = 0.06).

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Progression-free survival (PFS) according to ELN2017 did not reach statistical significance, possibly due to the small number of patients included (p = 0.465) with an estimated 2-year PFS of 50%, 30.8% and 45.8% in the favorable, intermediate and unfavorable group, respectively.

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Focusing on patients with CR before alloSCT, those with no detection of minimal residual disease (MRD-) showed a trend towards higher RFS compared to MRD + patients with a 2-y-RFS of 79% versus 47% (ns).

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In BM aspirations performed during the course of therapy, a decreasing trend in CD34 + cell numbers was observed.

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Univariate analysis for PGF risk factors showed significance for cryopreserved graft (HR 3.26; 1.65-6.42; p = 0.001) and major ABO mismatch between host and donor (HR 2.43; 1.22-4.86; p = 0.012), whereas donor age (HR 1.02; 0.99-1.04; p = 0.119) and prophylactic G-CSF (HR 1.86; 0.94-3.69; p = 0.076) were borderline significant.

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