Determination of Anti-drug Antibody Affinity in Clinical Study Samples Provides a Tool for Evaluation of Immune Response Maturation.

Figure 5 shows that for all patient subsets tested, the K D measurements showed a trend towards lower K D (higher affinity) as time progressed, consistent with a maturing immune response against PF-06480605.

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Figure 8A shows a clear trend of decreasing K D (increasing affinity) as ADA log titer increased (Pearson correlation coefficient ( r ) = − 0.402).

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