MicroRNA profiling of paediatric AML with FLT-ITD or MLL-rearrangements: Expression signatures and in vitro modulation of miR-221-3p and miR-222-3p with BRD4/HATs inhibitors.

Oncol Rep · 2022 · PMC9647495 · PMID 36321792

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did not reach statistical significanceno p-value reported

miR-222-3p demonstrated a trend towards downregulation with coupled treatment in all cell-lines, but it did not reach statistical significance ( Fig. 2A , lower panel).

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a clear trendno p-value reported

The expression of miR-221-3p expression showed a clear trend towards downregulation, reaching statistical significance in MV-4-11 cells when treated with JQ1, curcumin or the combination of both ( Fig. 2A , upper panel). miR-222-3p demonstrated a trend towards downregulation with coupled treatment in all cell-lines, but it did not reach statistical significance ( Fig. 2A , lower panel).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

MicroRNA profiling of paediatric AML with <i>FLT-ITD</i> or <i>MLL</i>-rearrangements: Expression signatures and <i>in vitro</i> modulation of miR-221-3p and miR-222-3p with BRD4/HATs inhibitors.

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