Despite not being statistically significant after FDR correction, a negative trend was detected between MDS-UPDRS-III scores and prefrontal cortex ⇀ motor cortex connectivity (Fig. 5a ).
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Treadmill training in Parkinson's disease is underpinned by the interregional connectivity in cortical-subcortical network.
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In this study, a positive trend between brainstem ⇀ subcortical region connectivity and UPDRS-Total score (Fig. 5b ) was also observed, suggesting that higher connectivity is related to poorer UPDRS-Total performance.
These modifications showed a trend towards the level of the control group, suggesting patterns of neural changes following TT.