Thus, although most analyses shown in 6B–E (derived from two biological replicates) did not reach statistical significance, there is a clear trend suggesting that the anti-proliferative activity of the low-dose combination results from either post-mitotic cell death or induction of post-mitotic cell cycle arrest or senescence.
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Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors.
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