Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients.

46 There was a trend of higher median levels of Abs against all five antigens in the hospitalized group as compared to the ambulatory group, but the differences did not reach statistical significance and the individual Ab levels from the two groups essentially overlapped ( Figures 1 C and S2 A), indicating that the two groups of patients could not be differentiated by their anti-SARS-CoV-2 Ab levels.

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Interestingly, when the specimens were divided according to the disease severity, the S2-specific Ig levels overtime showed a trend of positive slope for the hospitalized patients and negative slope for the ambulatory patients ( Figure 1 F).

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