A novel signature to predict the neoadjuvant chemotherapy response of bladder carcinoma: Results from a territory multicenter real-world study.

However, another study found that the association between ERCC2 missense mutations and pathologic response did not reach statistical significance, while only ERBB2 mutations were significantly related to response ( Groenendijk et al., 2016 ).

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Specifically, patients who achieve a pathologic response (downstaging to ≤ pT1 at cystectomy) after NAC have a strong trend of better OS and disease-specific survival (DSS) ( Grossman et al., 2003 ).

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