Mesoscale cortex-wide neural dynamics predict self-initiated actions in mice several seconds prior to movement.

Longitudinal cortical network dynamics support shortening of EDTs Considering the number of rewarded lever pulls per session, we found that between the first and last days of the experiment three of the mice (M2, M3, and M6) increased the number of rewarded lever pulls while one additional mouse (M5) also had a positive trend (with pval of 0.13); one of the mice (M1) decreased its number of pulls per day and the remaining mouse did not have statistically significant changes ( Figure 4a ; Pearson correlation values provided in figure insets; see Methods).

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There is a clear trend here despite the statistical results, which calls into question the statistical technique used to assess the relationships in Figure 6g.

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This trend was confirmed by examining the mean EDT at each lockout time point which showed in nearly all mice (excluding M2) a strong trend for the mean EDT to shorten with increasing lockout ( Figure 6h ).

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