Levels of the arachidonoyl-containing phospholipid 1-palmitoyl-2-arachidonoyl- sn -glycero-3-phosphocholine (16:0/20:4, PC/PAPC) were significantly decreased in control macrophages after LPS stimulation, while in ACC-deficient macrophages, levels of PAPC trended lower in response to LPS but did not reach statistical significance ( Fig. 6E ).
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Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.
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On the other hand, analysis of mitochondrial function in ACC Δ LysM BMDMs demonstrated a nonsignificant trend to increased basal and maximal oxygen consumption rate (OCR) (fig.
Unstimulated ACC-deficient BMDMs showed a trend toward an increase in cholesterol levels compared with flox controls ( Fig. 6G ).