Pathological 25 kDa C-Terminal Fragments of TDP-43 Are Present in Lymphoblastoid Cell Lines and Extracellular Vesicles from Patients Affected by Frontotemporal Lobar Degeneration and Neuronal Ceroidolipofuscinosis Carrying a <i>GRN</i> Mutation.

Int J Mol Sci · 2022 · PMC9694984 · PMID 36430231

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showed a trendno p-value reported

Our results showed a trend of concentration decreasing in EVs derived from GRN -mutated LCLs, although not reaching statistical significance.

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did not reach statistical significanceno p-value reported

Plasma FL p-TDP-43 was generally higher in FTLD with pathological TDP-43 changes (included 6 GRN -mutated patients), although this did not reach statistical significance [ 32 ].

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