Performance Status and Long-Term Outcomes in Cancer-Associated Pulmonary Embolism: Insights From the Hokusai-VTE Cancer Study.

16 In our analysis, when death not related to VTE was treated as a competing event, the subdistribution hazard related to the changes in ECOG status marginally failed to reach statistical significance with regard to the composite outcome.

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Furthermore, the point estimates for HRs on the basis of time-dependent ECOG changes suggested that patients with worsening ECOG status over the follow-up period had an increased risk both for VTE recurrence (adjusted HR: 1.25) and for major bleeding (adjusted HR: 1.56), after adjusting for age, randomized anticoagulation arm, and bleeding risk factors; however, the results did not reach statistical significance (95% CIs: 0.74-2.10 and 0.91-2.67, respectively).

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