Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.

However, Rap1 KI/WT mice had RAP1 levels comparable to those of WT mice ( Fig 1F ), yet showed a trend for higher body weight and fasting blood glucose levels with a HFHS diet ( S8E and S8G Fig ).

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There was a significant trend toward increased tumor burden with increasing Rap1 KI dosage from WT to Rap1 WT/KI to Rap1 KI/KI and a significant increase in tumor incidence in Rap1 KI/KI mice, with a prevalence for tumor formation in the liver and spleen ( Fig 6C and S5 Table ).

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