The association of FKBP5 gene methylation, adolescents' sex, and depressive symptoms among Chinese adolescents: a nested case-control study.

BMC Psychiatry · 2022 · PMC9710023 · PMID 36451133

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0550

boldest claim

The sentences

borderline significantP = 0.05actually significant

The prevalence of having current drunk alcohol was higher among females (50.9%) than male students (40.1%), which was only borderline significant ( P = 0.05).

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approaching significanceP = 0.055so close (0.05 < p ≤ 0.1)

In addition, the hypomethylation of FKBP5 -12 CpG 1 was approaching significance after adjustment for social-environmental factors (a OR = 0.77; P = 0.055), which indicated that no independent association was detected between hypomethylation of FKBP5 CpG sites and persistent depressive symptoms.

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did not reach statistical significanceno p-value reported

[ 23 ] in a case-control study, conducted genome-wide methylation research among 190 children and also discovered that children’s depression scores were significantly predicted by methylation in CpG sites of FKBP5 , but did not reach statistical significance after correcting for whole genome testing.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.