ACNP 61^st Annual Meeting: Poster Abstracts P1 - P270.

To reduce the feature space, we first selected only the features which showed a trend-level correlation with the total CAM score (p < 0.10), then visually inspected correlation plots to remove redundancy.

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Relative to placebo, E2 administration reduced perimenstrual increases in depression (Est = -.41, SE = .17, p = .01; Effect size note: response scale range=5) and perceived stress (Est = -.33, SE = .15 p = .03), although a corresponding greater reduction in suicidal ideation severity did not reach statistical significance (Est = -.15, SE = .10, p = .17).

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However, a marginally significant interaction between rearing and sex was observed in social vigilance behavior during social anxiety testing on Day 2 (two-way ANOVA; rearing x sex: F(1,37) = 4.059, p = 0.051).

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