Phosphorus metabolism in the brain of cognitively normal midlife individuals at risk for Alzheimer's disease.

In the AD high-risk cohort, metabolite ratios in the AD meta region PCr/ATP, and Pi/ATP showed significant inverse associations with FDG uptake (P < 0.01), while PME/PDE showed a trend toward association (P = 0.018) (see Table 3 and Fig. 2 ).

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While there was a trend toward an inverse relationship between PME/PDE and FDG-SUV, this did not reach statistical significance, and further support the results in Rijpma et al.

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