Interestingly we observed a clear trend of upregulating SREBP1, PNPLA3 and TMS6F after induction of lipid droplet accumulation, followed by an inhibition of these genes by both simvastatin and lovastatin ( Supplementary Figure S3 ).
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Dissecting the multifaceted impact of statin use on fatty liver disease: a multidimensional study.
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The sentences
Statins seem to have a preventative effect on the presence of NAFLD, although this did not reach statistical significance (OR: 0.69 95% CI: 0.46–1.01), and further validation is warranted.