The Role of a Novel Generation of Emollients, 'Emollients Plus', in Atopic Dermatitis.

99 The ‘Prevention of AD By a Barrier Lipid Equilibrium Strategy’ (PEBBLES) pilot study showed a trend for decreased food sensitization at 6 and 12 months of age when emollients were used preventatively from birth, particularly when the lipid-rich emollient was introduced early (<2 weeks after birth) and used frequently (≥5 days per week).

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A trend for reduced AD incidence was observed with Restoraderm moisturizer compared with control at 12 months (13.2% vs 25.0%, respectively; p = 0.204) and 2 years (19.4% vs 31.0%, respectively; p = 0.296), but did not reach statistical significance. 97 However, there is conflicting evidence on the preventative use of emollients for AD.

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