A Novel PiRNA Enhances CA19-9 Sensitivity for Pancreatic Cancer Identification by Liquid Biopsy.

J Clin Med · 2022 · PMC9784851 · PMID 36555927

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.4440

boldest claim

The sentences

a strong trend toward significancep = 0.051so close (0.05 < p ≤ 0.1)

The statistical analysis of the IC revealed a strong trend toward significance between the expression of tumour and healthy samples ( p = 0.051) ( Figure 3 B).

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did not reach statistical significancep = 0.444not close (p > 0.1)

Furthermore, we found that piR-162725 could identify 14% of patients that were negative for CA19-9, which supports its potential role as a diagnostic biomarker However, the association between tumour stages (early and advanced) and the positive expression of piR-162725 did not reach statistical significance ( p = 0.444).

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highly significantno p-value reported

The data integration and analysis after validation with human tissues revealed a highly significant association between one common piRNA and untransformed cells or tissues ( pir-366845 ) and a high statistical significance for two common piRNAs with tumour samples ( piR-168112 and piR-162725 ) ( Figure 1 D).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.