A Reduction of Calcineurin Inhibitors May Improve Survival in Patients with De Novo Colorectal Cancer after Liver Transplantation.

Medicina (Kaunas) · 2022 · PMC9785597 · PMID 36556957

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

showed a trendp = 0.054so close (0.05 < p ≤ 0.1)

Statistically significant improved survival was found in Kaplan–Meier analysis for patients in the RIM group with 83.46 (8.4–193.1) months in RIM and 24.8 (0.5–298.9) months in the maintenance group (log rank = 0.02) and showed a trend in multivariate cox regression ( p = 0.054, HR = 14.3, CI = 0.96–213.67).

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did not reach statistical significanceno p-value reported

The subgroup analysis of patients with regard to N- and M-status showed trends for a survival benefit for patients with RIM but did not reach statistical significance except for short-term survival in patients with M1 status (see Figure 2 ).

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