Regulation of B cell receptor signalling by Epstein-Barr virus nuclear antigens.

CD79A and CD79B were previously reported as significantly down-regulated by EBNA2 in the B cell lymphoma cell line BJAB [ 17 ], but in our Taqman analysis using duplicate ER-EB 2.5 RNA samples, repression of these genes did not reach statistical significance.

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For EBNA2, where a higher number of highly significant binding sites had identical P -values, binding sites with a P -value of 10 −310 or lower (526 sites) were used for analysis.

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Our analysis also highlighted potential new repressed target genes including NFATC4 (which showed a trend to repression) and IFITM1 (dCt P -value 0.003).

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