NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet.

Nudt7 -deficient hepatocytes isolated from fasted mice also tended to exhibit lower rates of mitochondrial fatty acid oxidation than WT hepatocytes, but the difference did not reach statistical significance.

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The liver of Nudt7 -/- females fed the CD also exhibited a significant downregulation in the gene encoding monoglyceride lipase, Mgll , and a strong trend toward increased triacylglycerol excretion in the feces ( Fig. 7 G ), which could contribute to the diminished concentration of nonesterified fatty acids in the liver of these mice.

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The livers of Nudt7 -/- females showed highly significant changes in long-chain polyunsaturated fatty acids on both diets ( Fig. 5 , D and E ).

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