CLIC-01: Manufacture and distribution of non-cryopreserved CAR-T cells for patients with CD19 positive hematologic malignancies.

Front Immunol · 2022 · PMC9806210 · PMID 36601119

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did not reach statistical significanceno p-value reported

However, these trends in cytokine levels did not reach statistical significance.

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nominally significantno p-value reported

There was a nominally significant association between CD28 expression on CD4+ T cells and response (CR or PR) at day 180 after CAR-T cell infusion (91.3% CD28+, range 56.9–99.9% for responders versus 79.4%, range 44.6–99.9% for non-responders, p=0.048, t-test), but no other statistically significant associations between clinical outcomes and the frequencies of immune cell subsets in PBMC samples or the infusion products.

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